Journal article
Julia A. Grummisch, N. Jadavji, Patrice D. Smith
Neural Regeneration Research, 2016
Neural Regeneration Research, 2016
Semantic Scholar
DOI
PubMedCentral
PubMed
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APA
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Grummisch, J. A., Jadavji, N., & Smith, P. D. (2016). The pleiotropic effects of tissue plasminogen activator in the brain: implications for stroke recovery. Neural Regeneration Research.
Chicago/Turabian
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Grummisch, Julia A., N. Jadavji, and Patrice D. Smith. “The Pleiotropic Effects of Tissue Plasminogen Activator in the Brain: Implications for Stroke Recovery.” Neural Regeneration Research (2016).
MLA
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Grummisch, Julia A., et al. “The Pleiotropic Effects of Tissue Plasminogen Activator in the Brain: Implications for Stroke Recovery.” Neural Regeneration Research, 2016.
BibTeX Click to copy
@article{julia2016a,
title = {The pleiotropic effects of tissue plasminogen activator in the brain: implications for stroke recovery},
year = {2016},
journal = {Neural Regeneration Research},
author = {Grummisch, Julia A. and Jadavji, N. and Smith, Patrice D.}
}
Abstract
be inhibited by AG490 and/or SOCS3, can phosphorylate STAT3 through downstream signalling. The Raf/ MEK/ERK pathway can be inhibited by U0126 and involved in regulating gene transcription. The Raf/MEK/ERK pathway can also interact with the PI3K/Akt/mTOR pathway to phosphorylate S6. Activation of the PI3K/Akt/ mTOR pathway can be inhibited by the phsophatase, PTEN and/or rapamycin. PI3K/Akt/mTOR activation can trigger up-regulation of ribosomal p-S6 and protein translation.