Jadavji Laboratory



Biomedical Sciences

Southern Illinois University



Collaborations


Mitra Esfandiarei, PhD

PREPRINT: Esfandiarei M, Strash SGU, Covaleski A, Ille S, Li W, Jadavji NM* (2024) Maternal dietary deficiency in choline reduced levels of MMP-2 levels in blood and brain tissue of male offspring mice. https://www.biorxiv.org/content/10.1101/2024.07.15.603575v1

Esfandiarei M, Bottiglieri T, Jadavji NM* (2024) Modifying levels of maternal one-carbon metabolism through diet to study the impact offspring health outcomes. Journal of Visualized Experiments: In Press

Pull K, Folk R, Kang J, Jackson S, Gusek B, Esfandiarei M, Jadavji NM (2023) Maternal dietary choline deficiencies during pregnancy and lactation reduce cerebral blood flow in 3-month-old female mice offspring following ischemic stroke to the sensorimotor cortex.American Journal of Physiology – Heart and Circulatory Physiology. 325: H1354


Haiwei Gu, PhD

Poole J, Jasbi J, Pascual AS, North S, Kwatra N, Weissig V, Gu H, Bottiglieri T, Jadavji NM. (2022) Ischemic stroke and dietary vitamin B12 deficiency in old-aged females impaired motor function, increased ischemic damage size, and changed metabolite profiles in brain and cecum tissue. Nutrients, 14(14), 2960; https://doi.org/10.3390/nu14142960


Faculty Job Market Collaboration

PREPRINT: Mollet A, Hagan A, Smith CT, Kozik AJ, Jadavji NM*, & Haage A*. (2023) Beyond the Leaky Pipeline: A Quantitative Analysis of the Academic Job Market in Humanities and Social Sciences. https://osf.io/jzxst/ 
PREPRINT: Kozik AJ, Haga A, Jadavji NM, Smith CT, Haage A. (2022). The US academic job marker survives the SARS-COV-2 global pandemic. https://www.biorxiv.org/content/10.1101/2022.05.27.493714v1 
Fernandes JD, Sarabipor A, Smith CT, Niemi NM, Jadavji NM, Kozik AJ, Holehouse AS, Pejaver V, Symmons O, Filho AWB, Haage A. Research Culture: A survey-based analysis of the academic job market. eLife. 9: e54097 PMID: 32530420. PMCID: PMC7360372.

Teodoro Bottiglieri, PhD

Yahn GB, Wasek B, Bottiglieri T, Malysheva O, Caudill MA, Jadavji NM*. (2023). A dietary vitamin B12 deficiency impairs motor function and changes neuronal survival and choline metabolism after ischemic stroke to the sensorimotor cortex in middle aged male and female mice. Nutritional Neuroscience, In Press https://doi.org/10.1080/1028415X.2023.2188639.
 Clementson M, Hurley L, Coonrod S, Bennett C, Marella P, Pascual AS, Pull K, Wasek B, Bottiglieri T, Malysheva O, Caudill M, Jadavji NM*. (2023).  Maternal dietary deficiencies in folates or choline during pregnancy and lactation worsen stroke outcome in 3-month-old male and female mouse offspring, Neural Regeneration Research. 18:2443-2448
Jadavji NM, Mosnier H, Kelly E, Lawrence K, Cruickshank S, Stacey S, McCall A, Dhatt S, Arning E, Bottiglieri T, Smith PD (2019) One-carbon metabolism supplementation improves outcome after stroke in aged male MTHFR-deficient mice. Neurobiology of disease. https://doi.org/10.1016/j.nbd.2019.104613


Ulrich Dirnagl, MD

Dam K, Füchtemeier M, Farr TD, Boehm-Strum P, Foddis M, Dirnagl U, Jadavji NM. (2017) Deficiencies in methylenetetrahydrofolate reductase and dietary folic acid alter choline metabolism during chronic hypoperfusion. Behavioral Brain Research, 321:201-208. PMID: 28087280.

​Jadavji NM, Wieske F, Dirgnal U, Winter C. (2015) Methylenetetrahydrfolate reductase deficiency alters levels of monoamine neurotransmitters, glutamate and gamma aminobutyric acid in brain tissue. Molecular Genetics and Metabolism and Genetics Reports, 3:1-4. PMID: 26937386.

Jadavji NM, Farr TD, Lips L, Khalil A, Boehm-Sturm P, Harms C, Foddis M, Füchtemeier M, Dirnagl U. (2015) Elevated levels of homocysteine, deficiencies in folic acid and uracil-DNA glycosylase impair learning in a mouse model of vascular cognitive impairment. Behavioural Brain Research, 283: 215-226. PMID: 2565513.

​Shawn Hayley, PhD

Jadavji NM*, Murray LK, Emmerson JT, Rudyk CA, Hayley S, Smith PD. A genetic deficiency in one-carbon metabolism increases oxidative stress in a mouse mode of Parkinson’s disease. Toxicological Sciences. 169:25-33. PMID: 22521626. PMCID: PMC6484892.

Bill Willmore, PhD

Jadavji NM, Emmerson JT, Shanmugalingam U, Willmore WG, MacFarlane AJ, Smith P. (2018)  MTHFR-deficiency increases vulnerability to stroke: in vitro and in vivo. Experimental Neurology. 309:14-22.. PMID: 30055159.

​Jadavji NM, Emmerson JE, Willmore WG, MacFarlane AJ, Smith PD. (2017) B-vitamin and choline supplementation increases neuroplasticity and recovery after stroke. Neurobiology of Disease, 103:89-100. PMID: 28396257.​
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