Jadavji Laboratory



Deparment Biomedical Sciences, Division of Molecular and Integrative Physiology

Southern Illinois University



Reduced brain volume and impaired memory in betaine homocysteine S-methyltransferase knockout mice.


Journal article


E. A. Prieur, E. Pjetri, S. Zeisel, N. Jadavji
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2017

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APA   Click to copy
Prieur, E. A., Pjetri, E., Zeisel, S., & Jadavji, N. (2017). Reduced brain volume and impaired memory in betaine homocysteine S-methyltransferase knockout mice. Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquee, Nutrition Et Metabolisme.


Chicago/Turabian   Click to copy
Prieur, E. A., E. Pjetri, S. Zeisel, and N. Jadavji. “Reduced Brain Volume and Impaired Memory in Betaine Homocysteine S-Methyltransferase Knockout Mice.” Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme (2017).


MLA   Click to copy
Prieur, E. A., et al. “Reduced Brain Volume and Impaired Memory in Betaine Homocysteine S-Methyltransferase Knockout Mice.” Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquee, Nutrition Et Metabolisme, 2017.


BibTeX   Click to copy

@article{e2017a,
  title = {Reduced brain volume and impaired memory in betaine homocysteine S-methyltransferase knockout mice.},
  year = {2017},
  journal = {Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme},
  author = {Prieur, E. A. and Pjetri, E. and Zeisel, S. and Jadavji, N.}
}

Abstract

Using a mouse model, this study examined the impact of lack of betaine homocysteine S-methyltransferase (BHMT) on neurological function. Bhmt-/- mice maintained on a control diet had elevated concentrations of homocysteine, reduced total brain magnetic resonance imaging (MRI) volume, as well as impaired reference and short-term memories. The results of this study indicate that the absence of BHMT may play a role in neurological function.